DEVELOPMENT / REPRODUCTION / GENOMICS发育 / 生殖 / 基因组学

Gene regulation in development and reproduction.发育与生殖中的基因调控

We study embryonic gene regulation, meiotic chromatin regulation and transcript diversity through experimental and computational approaches.结合实验与计算方法，研究胚胎基因调控、减数分裂中的染色质调控与转录本多样性。

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Guangzhou Medical University · Panyu Campus广州医科大学 · 番禺校区

Science Building and Laboratory Animal Center during construction, 2023.科技大楼与实验动物中心，2023 年建设期实景。

Photo: GMU / Nanfang Daily图片来源：广州医科大学 / 南方日报

GMU-GIBH Joint School of Life Sciences广州医科大学—中国科学院广州生物医药与健康研究院联合生命科学学院DEVELOPMENT / REPRODUCTION / GENOMICS发育 / 生殖 / 基因组学

RESEARCH IN FIGURES从论文看研究

Research areas研究方向

Complete Figure 1: mouse sample and sequencing workflow, transcript classes, sample correlations, PCA, transcript lengths, exon counts and isoform counts. — Figure 1图 1Wu et al. · Journal of Ovarian Research (2026)Wu 等 · Journal of Ovarian Research（2026） · Source出处 · CC BY-NC-ND 4.0

TRANSCRIPTOME DIVERSITY转录组多样性

2026 · Journal of Ovarian Research

Full-length transcriptomic profiling reveals age-associated isoform remodeling and altered coding potential in the mouse ovary

Long-read RNA sequencing profiles full-length transcripts in granulosa cells and oocytes from young and aged mice. The study identifies age-associated isoform changes, alternative polyadenylation and differences in predicted coding potential.通过长读长 RNA 测序解析年轻与衰老小鼠颗粒细胞和卵母细胞的全长转录本，识别与年龄相关的异构体变化、可变多聚腺苷酸化及预测编码潜能差异。

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Complete Figure 1: H3K18cr genomic profiles, peak statistics and immunostaining across mouse gametes and early embryos, with all original labels and microscopy scale bars. — Figure 1图 1Yuan et al. · Advanced Science (2026)Yuan 等 · Advanced Science（2026） · Source出处 · CC BY 4.0

EARLY DEVELOPMENT早期发育

2026 · Advanced Science

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

The study maps H3K18 crotonylation in mouse gametes and preimplantation embryos. It examines how remodeling of this histone mark interacts with zygotic genome activation and early development.研究绘制小鼠配子与植入前胚胎的 H3K18 巴豆酰化图谱，探索这一组蛋白修饰的重塑与合子基因组激活及早期发育之间的联系。

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Complete Figure 1: human embryo study design, chromatin accessibility, H3K27me3 and DNA methylation patterns, allele-related expression and imprinted-gene genome tracks. — Figure 1图 1Yuan et al. · National Science Review (2024)Yuan 等 · National Science Review（2024） · Source出处 · CC BY 4.0

EARLY DEVELOPMENT早期发育

2024 · National Science Review

Allelic reprogramming of chromatin states in human early embryos

Parental epigenomic maps of human early embryos reveal allele-specific chromatin reprogramming. Comparisons with mouse embryos identify differences in parental epigenetic states and genomic imprinting.通过人类早期胚胎的亲本表观基因组图谱，刻画等位基因特异的染色质重编程，并比较人和小鼠在亲本表观遗传状态及基因组印记上的差异。

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Complete Figure 1: human parthenogenetic and androgenetic embryo design, gene-level RNA-seq heatmap and newly transcribed gene comparisons. — Figure 1图 1Yuan et al. · Cell Discovery (2023)Yuan 等 · Cell Discovery（2023） · Source出处 · CC BY 4.0

EARLY DEVELOPMENT早期发育

2023 · Cell Discovery

Human zygotic genome activation is initiated from paternal genome

Using human parthenogenetic and androgenetic embryos, the study investigates parental contributions to zygotic genome activation. It identifies paternal expression of ZNF675 and LSM1 as part of the regulatory process.利用人类孤雌与孤雄胚胎研究双亲基因组对合子基因组激活的贡献，并探讨父源表达的 ZNF675 和 LSM1 在这一过程中的作用。

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Complete Figure 4: DMC1, ZCWPW1 and ATAC-seq genome tracks and heatmaps comparing wild-type, Zcwpw1, Prdm9 and Spo11 mutant mouse testes. — Figure 4图 4Yuan et al. · Genome Biology (2022)Yuan 等 · Genome Biology（2022） · Source出处 · CC BY 4.0

CHROMATIN REGULATION染色质调控

2022 · Genome Biology

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

The study investigates how the histone reader ZCWPW1 connects histone modifications with chromatin accessibility at meiotic recombination hotspots. The results link this regulation to homologous recombination during DNA double-strand break repair.研究探讨组蛋白修饰识别蛋白 ZCWPW1 如何联结减数分裂重组热点处的组蛋白修饰与染色质可及性，以及这一调控与 DNA 双链断裂同源重组修复的关系。

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EARLY DEVELOPMENT早期发育

Embryos & epigenetic reprogramming早期胚胎与表观遗传重编程

Zygotic genome activation and chromatin reprogramming in early embryos.早期胚胎中的合子基因组激活与染色质重编程。

Related research相关研究

CHROMATIN REGULATION染色质调控

Meiosis and chromatin regulation减数分裂与染色质调控

Investigating histone modifications, chromatin accessibility and meiotic regulation.研究组蛋白修饰、染色质可及性与减数分裂调控。

Related research相关研究

TRANSCRIPTOME DIVERSITY转录组多样性

Long reads & single-cell transcriptomics长读长与单细胞转录组

Long-read and single-cell analyses of transcript isoforms and allelic expression.转录本异构体与等位基因表达的长读长及单细胞分析。

Related research相关研究

Selected publications精选研究成果

2026

Journal of Ovarian Research

Full-length transcriptomic profiling reveals age-associated isoform remodeling and altered coding potential in the mouse ovary

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2026

bioRxivPreprint · not peer reviewed预印本 · 未经同行评审

ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant calling

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2026

Advanced Science

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Read the paper阅读论文

All selected publications全部精选论文

Publication updates论文动态

View all updates查看全部动态

2026-07-08

Gene regulation in development and reproduction.发育与生殖中的基因调控

Research areas研究方向

Full-length transcriptomic profiling reveals age-associated isoform remodeling and altered coding potential in the mouse ovary

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Allelic reprogramming of chromatin states in human early embryos

Human zygotic genome activation is initiated from paternal genome

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

Embryos & epigenetic reprogramming早期胚胎与表观遗传重编程

Meiosis and chromatin regulation减数分裂与染色质调控

Long reads & single-cell transcriptomics长读长与单细胞转录组

Selected publications精选研究成果

Full-length transcriptomic profiling reveals age-associated isoform remodeling and altered coding potential in the mouse ovary

ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant calling

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Publication updates论文动态

Full-length view of the aging mouse ovary从全长转录本看小鼠卵巢衰老

ANCHOR preprint postedANCHOR 预印本发布

Mapping histone crotonylation in early development解析早期发育中的组蛋白巴豆酰化

Article figure论文原图

Gene regulation in development and reproduction.发育与生殖中的 基因调控

Research areas研究方向

Full-length transcriptomic profiling reveals age-associated isoform remodeling and altered coding potential in the mouse ovary

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Allelic reprogramming of chromatin states in human early embryos

Human zygotic genome activation is initiated from paternal genome

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

Embryos & epigenetic reprogramming早期胚胎与表观遗传重编程

Meiosis and chromatin regulation减数分裂与染色质调控

Long reads & single-cell transcriptomics长读长与单细胞转录组

Selected publications精选研究成果

Full-length transcriptomic profiling reveals age-associated isoform remodeling and altered coding potential in the mouse ovary

ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant calling

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Publication updates论文动态

Full-length view of the aging mouse ovary从全长转录本看小鼠卵巢衰老

ANCHOR preprint postedANCHOR 预印本发布

Mapping histone crotonylation in early development解析早期发育中的组蛋白巴豆酰化

Gene regulation in development and reproduction.发育与生殖中的基因调控